Vitamin A turnover in rats as influenced by vitamin A status

K. C. Lewis, M. H. Green, B. A. Underwood

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38 Scopus citations


Vitamin A turnover was studied in rats fed vitamin A-sufficient (+A) or vitamin A-deficient (-A) diets for 24-25 days. Hepatic vitamin A stores of the +A group (543 μg) were significantly larger than those of the -A group (11 μg) and similarly, the plasma vitamin A concentration of the +A group (56 μg/dl) was significantly higher than that of the -A group (26 μg/dl). Rats were injected intravenously with plasma containing tritium-labeled retinol (3R-ROH) obtained from vitamin A-deficient donor rats previously fed 3H-ROH. Plasma samples from injected recipients were collected over a 48-hour period. Kinetic analysis of plasma tracer concentration versus time curves indicated that the data fit a three-pool model. The plasma vitamin A turnover rate of the +A group was significantly more rapid than that of the -A group (5.19 versus 1.98 μg/hour). Plasma fractional turnover rates for the +A group (1.31 hour-1) were not significantly different from those of the -A group (0.90 hour-1). The data suggest that for both dietary groups, the metabolism of retinol associated with the prealbumin and retinol-binding protein complex involved extensive recycling among the liver plasma, interstitial fluid and peripheral tissues.

Original languageEnglish (US)
Pages (from-to)1135-1144
Number of pages10
JournalJournal of Nutrition
Issue number7
StatePublished - 1981

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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