Vitamin D deficiency is associated with decreased lung function in Chinese adults with asthma

Fei Li, Min Peng, Lei Jiang, Qi Sun, Kui Zhang, Fuzhi Lian, Augusto A. Litonjua, Jinming Gao, Xiang Gao

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


Background: Vitamin D deficiency has been associated with markers for allergy and asthma severity in children with asthma. However, its association with Chinese adult asthmatics has not been studied. Objective: To examine whether vitamin D status is associated with lung function and total serum IgE in Chinese adults with newly diagnosed asthma. Methods: We conducted a cross-sectional study including 435 Chinese patients aged >18 years with newly diagnosed asthma. Vitamin D status was assessed by measuring serum 25 hydroxyvitamin D (25OHD) concentrations. The primary outcomes included airflow limitation, as measured by the forced expiratory volume in 1 s (FEV 1), FEV1 % predicted, and FEV1/forced vital capacity (FVC), and serum total IgE concentration. Results: Vitamin D deficiency was prevalent in Chinese adults with asthma, with 88.9% of the subjects having 25OHD <50 nmol/l. Serum 25OHD concentration was positively correlated with FEV1 % predicted (p = 0.02, r = 0.12). After adjusting for age, sex, body mass index, smoking, month of blood collection, and symptom duration, we found significant positive associations between 25OHD concentrations and FEV1 (in liters), FEV1 % predicted, and FEV 1/FVC (p for trend < 0.05 for all). The adjusted odds ratios for the highest versus the lowest 25OHD quartile were 0.50 (0.26-0.96) for FEV 1 <75% predicted and 0.44 (0.20-0.95) for FEV1/FVC% <0.75. There was no significant association between 25OHD concentrations and total IgE. Conclusions: Vitamin D deficiency was highly prevalent in Chinese asthma patients, and vitamin D status was associated with lung function.

Original languageEnglish (US)
Pages (from-to)469-475
Number of pages7
Issue number6
StatePublished - May 2011

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine


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