Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis

William P. Sexauer; Anas Hadeh; Pamela A. Ohman-Strickland; Robert L. Zanni; Laurie Varlotta; Douglas Holsclaw; Stanley Fiel; Gavin R. Graff; Arthur Atlas; Dorothy Bisberg; Denis Hadjiliadis; Suzanne H. Michel; Daria Mintz; Rebanta Chakraborty; Bridget Marra; Paula Lomas; Tara Ward; Meagen Sassman; Giovanna C. Imbesi; Diane M. Kitch; Allison M. Mallowe

doi:10.1016/j.jcf.2014.12.006

Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis

William P. Sexauer, Anas Hadeh, Pamela A. Ohman-Strickland, Robert L. Zanni, Laurie Varlotta, Douglas Holsclaw, Stanley Fiel, Gavin R. Graff, Arthur Atlas, Dorothy Bisberg, Denis Hadjiliadis, Suzanne H. Michel, Daria Mintz, Rebanta Chakraborty, Bridget Marra, Paula Lomas, Tara Ward, Meagen Sassman, Giovanna C. Imbesi, Diane M. KitchAllison M. Mallowe

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44 Scopus citations

Abstract

Background: Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function in CF is unknown. Methods: Data were abstracted from clinically stable CF patients who had pulmonary function studies and serum 25-hydroxyvitamin D [25(OH)D, ng/ml] levels drawn within 2. months of each other. Findings were adjusted for multiple variables known to affect pulmonary function in CF. Results: Enrollees totaled 597. Overall mean 25(OH)D level was 29.6±12.8ng/ml (SD). Serum 25(OH)D levels showed a significant correlation with forced expiratory volume in 1s (FEV₁) % predicted (r=0.20, p<0.0001) and forced vital capacity % predicted (r=0.13, p=0.0019). Multivariate analysis revealed that serum 25(OH)D remained an independent predictor of FEV₁ % predicted even after controlling for multiple other factors known to affect CF lung function. Conclusions: Serum 25(OH)D levels are significantly associated with pulmonary function in CF. Further study is required to determine whether this association is causal.

Original language	English (US)
Pages (from-to)	497-506
Number of pages	10
Journal	Journal of Cystic Fibrosis
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/j.jcf.2014.12.006
State	Published - Jul 1 2015

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Pulmonary and Respiratory Medicine

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Sexauer, W. P., Hadeh, A., Ohman-Strickland, P. A., Zanni, R. L., Varlotta, L., Holsclaw, D., Fiel, S., Graff, G. R., Atlas, A., Bisberg, D., Hadjiliadis, D., Michel, S. H., Mintz, D., Chakraborty, R., Marra, B., Lomas, P., Ward, T., Sassman, M., Imbesi, G. C., ... Mallowe, A. M. (2015). Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis. Journal of Cystic Fibrosis, 14(4), 497-506. https://doi.org/10.1016/j.jcf.2014.12.006

@article{30dc03a301f64e55b449aa8df941b249,

title = "Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis",

abstract = "Background: Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function in CF is unknown. Methods: Data were abstracted from clinically stable CF patients who had pulmonary function studies and serum 25-hydroxyvitamin D [25(OH)D, ng/ml] levels drawn within 2. months of each other. Findings were adjusted for multiple variables known to affect pulmonary function in CF. Results: Enrollees totaled 597. Overall mean 25(OH)D level was 29.6±12.8ng/ml (SD). Serum 25(OH)D levels showed a significant correlation with forced expiratory volume in 1s (FEV1) % predicted (r=0.20, p<0.0001) and forced vital capacity % predicted (r=0.13, p=0.0019). Multivariate analysis revealed that serum 25(OH)D remained an independent predictor of FEV1 % predicted even after controlling for multiple other factors known to affect CF lung function. Conclusions: Serum 25(OH)D levels are significantly associated with pulmonary function in CF. Further study is required to determine whether this association is causal.",

author = "Sexauer, {William P.} and Anas Hadeh and Ohman-Strickland, {Pamela A.} and Zanni, {Robert L.} and Laurie Varlotta and Douglas Holsclaw and Stanley Fiel and Graff, {Gavin R.} and Arthur Atlas and Dorothy Bisberg and Denis Hadjiliadis and Michel, {Suzanne H.} and Daria Mintz and Rebanta Chakraborty and Bridget Marra and Paula Lomas and Tara Ward and Meagen Sassman and Imbesi, {Giovanna C.} and Kitch, {Diane M.} and Mallowe, {Allison M.}",

note = "Publisher Copyright: {\textcopyright} 2014 European Cystic Fibrosis Society.",

year = "2015",

month = jul,

day = "1",

doi = "10.1016/j.jcf.2014.12.006",

language = "English (US)",

volume = "14",

pages = "497--506",

journal = "Journal of Cystic Fibrosis",

issn = "1569-1993",

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Sexauer, WP, Hadeh, A, Ohman-Strickland, PA, Zanni, RL, Varlotta, L, Holsclaw, D, Fiel, S, Graff, GR, Atlas, A, Bisberg, D, Hadjiliadis, D, Michel, SH, Mintz, D, Chakraborty, R, Marra, B, Lomas, P, Ward, T, Sassman, M, Imbesi, GC, Kitch, DM & Mallowe, AM 2015, 'Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis', Journal of Cystic Fibrosis, vol. 14, no. 4, pp. 497-506. https://doi.org/10.1016/j.jcf.2014.12.006

TY - JOUR

T1 - Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis

AU - Sexauer, William P.

AU - Hadeh, Anas

AU - Ohman-Strickland, Pamela A.

AU - Zanni, Robert L.

AU - Varlotta, Laurie

AU - Holsclaw, Douglas

AU - Fiel, Stanley

AU - Graff, Gavin R.

AU - Atlas, Arthur

AU - Bisberg, Dorothy

AU - Hadjiliadis, Denis

AU - Michel, Suzanne H.

AU - Mintz, Daria

AU - Chakraborty, Rebanta

AU - Marra, Bridget

AU - Lomas, Paula

AU - Ward, Tara

AU - Sassman, Meagen

AU - Imbesi, Giovanna C.

AU - Kitch, Diane M.

AU - Mallowe, Allison M.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Background: Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function in CF is unknown. Methods: Data were abstracted from clinically stable CF patients who had pulmonary function studies and serum 25-hydroxyvitamin D [25(OH)D, ng/ml] levels drawn within 2. months of each other. Findings were adjusted for multiple variables known to affect pulmonary function in CF. Results: Enrollees totaled 597. Overall mean 25(OH)D level was 29.6±12.8ng/ml (SD). Serum 25(OH)D levels showed a significant correlation with forced expiratory volume in 1s (FEV1) % predicted (r=0.20, p<0.0001) and forced vital capacity % predicted (r=0.13, p=0.0019). Multivariate analysis revealed that serum 25(OH)D remained an independent predictor of FEV1 % predicted even after controlling for multiple other factors known to affect CF lung function. Conclusions: Serum 25(OH)D levels are significantly associated with pulmonary function in CF. Further study is required to determine whether this association is causal.

AB - Background: Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function in CF is unknown. Methods: Data were abstracted from clinically stable CF patients who had pulmonary function studies and serum 25-hydroxyvitamin D [25(OH)D, ng/ml] levels drawn within 2. months of each other. Findings were adjusted for multiple variables known to affect pulmonary function in CF. Results: Enrollees totaled 597. Overall mean 25(OH)D level was 29.6±12.8ng/ml (SD). Serum 25(OH)D levels showed a significant correlation with forced expiratory volume in 1s (FEV1) % predicted (r=0.20, p<0.0001) and forced vital capacity % predicted (r=0.13, p=0.0019). Multivariate analysis revealed that serum 25(OH)D remained an independent predictor of FEV1 % predicted even after controlling for multiple other factors known to affect CF lung function. Conclusions: Serum 25(OH)D levels are significantly associated with pulmonary function in CF. Further study is required to determine whether this association is causal.

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UR - http://www.scopus.com/inward/citedby.url?scp=84937632482&partnerID=8YFLogxK

U2 - 10.1016/j.jcf.2014.12.006

DO - 10.1016/j.jcf.2014.12.006

M3 - Article

C2 - 25577127

AN - SCOPUS:84937632482

SN - 1569-1993

VL - 14

SP - 497

EP - 506

JO - Journal of Cystic Fibrosis

JF - Journal of Cystic Fibrosis

IS - 4

ER -

Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis

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