Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis

William P. Sexauer; Anas Hadeh; Pamela A. Ohman-Strickland; Robert L. Zanni; Laurie Varlotta; Douglas Holsclaw; Stanley Fiel; Gavin R. Graff; Arthur Atlas; Dorothy Bisberg; Denis Hadjiliadis; Suzanne H. Michel; Daria Mintz; Rebanta Chakraborty; Bridget Marra; Paula Lomas; Tara Ward; Meagen Sassman; Giovanna C. Imbesi; Diane M. Kitch; Allison M. Mallowe

doi:10.1016/j.jcf.2014.12.006

Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis

William P. Sexauer
, Anas Hadeh
, Pamela A. Ohman-Strickland
, Robert L. Zanni
, Laurie Varlotta
, Douglas Holsclaw
, Stanley Fiel
, Gavin R. Graff
, Arthur Atlas
, Dorothy Bisberg
, Denis Hadjiliadis
, Suzanne H. Michel
, Daria Mintz
, Rebanta Chakraborty
, Bridget Marra
, Paula Lomas
, Tara Ward
, Meagen Sassman
, Giovanna C. Imbesi
, Diane M. Kitch

Allison M. Mallowe

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Background: Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function in CF is unknown. Methods: Data were abstracted from clinically stable CF patients who had pulmonary function studies and serum 25-hydroxyvitamin D [25(OH)D, ng/ml] levels drawn within 2. months of each other. Findings were adjusted for multiple variables known to affect pulmonary function in CF. Results: Enrollees totaled 597. Overall mean 25(OH)D level was 29.6±12.8ng/ml (SD). Serum 25(OH)D levels showed a significant correlation with forced expiratory volume in 1s (FEV₁) % predicted (r=0.20, p<0.0001) and forced vital capacity % predicted (r=0.13, p=0.0019). Multivariate analysis revealed that serum 25(OH)D remained an independent predictor of FEV₁ % predicted even after controlling for multiple other factors known to affect CF lung function. Conclusions: Serum 25(OH)D levels are significantly associated with pulmonary function in CF. Further study is required to determine whether this association is causal.

Original language	English (US)
Pages (from-to)	497-506
Number of pages	10
Journal	Journal of Cystic Fibrosis
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/j.jcf.2014.12.006
State	Published - Jul 1 2015

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Pulmonary and Respiratory Medicine

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10.1016/j.jcf.2014.12.006

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Sexauer, W. P., Hadeh, A., Ohman-Strickland, P. A., Zanni, R. L., Varlotta, L., Holsclaw, D., Fiel, S., Graff, G. R., Atlas, A., Bisberg, D., Hadjiliadis, D., Michel, S. H., Mintz, D., Chakraborty, R., Marra, B., Lomas, P., Ward, T., Sassman, M., Imbesi, G. C., ... Mallowe, A. M. (2015). Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis. Journal of Cystic Fibrosis, 14(4), 497-506. https://doi.org/10.1016/j.jcf.2014.12.006

@article{30dc03a301f64e55b449aa8df941b249,

title = "Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis",

abstract = "Background: Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function in CF is unknown. Methods: Data were abstracted from clinically stable CF patients who had pulmonary function studies and serum 25-hydroxyvitamin D [25(OH)D, ng/ml] levels drawn within 2. months of each other. Findings were adjusted for multiple variables known to affect pulmonary function in CF. Results: Enrollees totaled 597. Overall mean 25(OH)D level was 29.6±12.8ng/ml (SD). Serum 25(OH)D levels showed a significant correlation with forced expiratory volume in 1s (FEV1) \% predicted (r=0.20, p<0.0001) and forced vital capacity \% predicted (r=0.13, p=0.0019). Multivariate analysis revealed that serum 25(OH)D remained an independent predictor of FEV1 \% predicted even after controlling for multiple other factors known to affect CF lung function. Conclusions: Serum 25(OH)D levels are significantly associated with pulmonary function in CF. Further study is required to determine whether this association is causal.",

author = "Sexauer, \{William P.\} and Anas Hadeh and Ohman-Strickland, \{Pamela A.\} and Zanni, \{Robert L.\} and Laurie Varlotta and Douglas Holsclaw and Stanley Fiel and Graff, \{Gavin R.\} and Arthur Atlas and Dorothy Bisberg and Denis Hadjiliadis and Michel, \{Suzanne H.\} and Daria Mintz and Rebanta Chakraborty and Bridget Marra and Paula Lomas and Tara Ward and Meagen Sassman and Imbesi, \{Giovanna C.\} and Kitch, \{Diane M.\} and Mallowe, \{Allison M.\}",

note = "Publisher Copyright: {\textcopyright} 2014 European Cystic Fibrosis Society.",

year = "2015",

month = jul,

day = "1",

doi = "10.1016/j.jcf.2014.12.006",

language = "English (US)",

volume = "14",

pages = "497--506",

journal = "Journal of Cystic Fibrosis",

issn = "1569-1993",

publisher = "Elsevier B.V.",

number = "4",

}

Sexauer, WP, Hadeh, A, Ohman-Strickland, PA, Zanni, RL, Varlotta, L, Holsclaw, D, Fiel, S, Graff, GR, Atlas, A, Bisberg, D, Hadjiliadis, D, Michel, SH, Mintz, D, Chakraborty, R, Marra, B, Lomas, P, Ward, T, Sassman, M, Imbesi, GC, Kitch, DM & Mallowe, AM 2015, 'Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis', Journal of Cystic Fibrosis, vol. 14, no. 4, pp. 497-506. https://doi.org/10.1016/j.jcf.2014.12.006

TY - JOUR

T1 - Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis

AU - Sexauer, William P.

AU - Hadeh, Anas

AU - Ohman-Strickland, Pamela A.

AU - Zanni, Robert L.

AU - Varlotta, Laurie

AU - Holsclaw, Douglas

AU - Fiel, Stanley

AU - Graff, Gavin R.

AU - Atlas, Arthur

AU - Bisberg, Dorothy

AU - Hadjiliadis, Denis

AU - Michel, Suzanne H.

AU - Mintz, Daria

AU - Chakraborty, Rebanta

AU - Marra, Bridget

AU - Lomas, Paula

AU - Ward, Tara

AU - Sassman, Meagen

AU - Imbesi, Giovanna C.

AU - Kitch, Diane M.

AU - Mallowe, Allison M.

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Background: Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function in CF is unknown. Methods: Data were abstracted from clinically stable CF patients who had pulmonary function studies and serum 25-hydroxyvitamin D [25(OH)D, ng/ml] levels drawn within 2. months of each other. Findings were adjusted for multiple variables known to affect pulmonary function in CF. Results: Enrollees totaled 597. Overall mean 25(OH)D level was 29.6±12.8ng/ml (SD). Serum 25(OH)D levels showed a significant correlation with forced expiratory volume in 1s (FEV1) % predicted (r=0.20, p<0.0001) and forced vital capacity % predicted (r=0.13, p=0.0019). Multivariate analysis revealed that serum 25(OH)D remained an independent predictor of FEV1 % predicted even after controlling for multiple other factors known to affect CF lung function. Conclusions: Serum 25(OH)D levels are significantly associated with pulmonary function in CF. Further study is required to determine whether this association is causal.

AB - Background: Vitamin D deficiency is common in CF. Whether vitamin D affects pulmonary function in CF is unknown. Methods: Data were abstracted from clinically stable CF patients who had pulmonary function studies and serum 25-hydroxyvitamin D [25(OH)D, ng/ml] levels drawn within 2. months of each other. Findings were adjusted for multiple variables known to affect pulmonary function in CF. Results: Enrollees totaled 597. Overall mean 25(OH)D level was 29.6±12.8ng/ml (SD). Serum 25(OH)D levels showed a significant correlation with forced expiratory volume in 1s (FEV1) % predicted (r=0.20, p<0.0001) and forced vital capacity % predicted (r=0.13, p=0.0019). Multivariate analysis revealed that serum 25(OH)D remained an independent predictor of FEV1 % predicted even after controlling for multiple other factors known to affect CF lung function. Conclusions: Serum 25(OH)D levels are significantly associated with pulmonary function in CF. Further study is required to determine whether this association is causal.

UR - https://www.scopus.com/pages/publications/84937632482

UR - https://www.scopus.com/pages/publications/84937632482#tab=citedBy

U2 - 10.1016/j.jcf.2014.12.006

DO - 10.1016/j.jcf.2014.12.006

M3 - Article

C2 - 25577127

AN - SCOPUS:84937632482

SN - 1569-1993

VL - 14

SP - 497

EP - 506

JO - Journal of Cystic Fibrosis

JF - Journal of Cystic Fibrosis

IS - 4

ER -

Vitamin D deficiency is associated with pulmonary dysfunction in cystic fibrosis

Abstract

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