TY - JOUR
T1 - Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease
AU - Cantorna, Margherita T.
AU - McDaniel, Kaitlin
AU - Bora, Stephanie
AU - Chen, Jing
AU - James, Jamaal
N1 - Funding Information:
This work was supported in part by grants to MTC from the National Institutes of Health/National Institutes of Neurologic and Stroke Grant [NS067563] and National Center for Complementary and Alternative Medicine and the Office of Dietary Supplements [AT005378].
Publisher Copyright:
© 2014 by the Society for Experimental Biology and Medicine.
PY - 2014/11/12
Y1 - 2014/11/12
N2 - The inflammatory bowel diseases are complex diseases caused by environmental, immunological, and genetic factors. Vitamin D status is low in patients with inflammatory bowel diseases, and experimental inflammatory bowel diseases are more severe in vitamin D-deficient or vitamin D receptor knockout animals. Vitamin D is beneficial in inflammatory bowel diseases because it regulates multiple checkpoints and processes essential for homeostasis in the gut. Vitamin D inhibits IFN-γ and IL-17 production while inducing regulatory T cells. In addition, vitamin D regulates epithelial cell integrity, innate immune responses, and the composition of the gut microbiota. Overall, vitamin D regulates multiple pathways that maintain gastrointestinal homeostasis. The data support improving vitamin D status in patients with inflammatory bowel diseases.
AB - The inflammatory bowel diseases are complex diseases caused by environmental, immunological, and genetic factors. Vitamin D status is low in patients with inflammatory bowel diseases, and experimental inflammatory bowel diseases are more severe in vitamin D-deficient or vitamin D receptor knockout animals. Vitamin D is beneficial in inflammatory bowel diseases because it regulates multiple checkpoints and processes essential for homeostasis in the gut. Vitamin D inhibits IFN-γ and IL-17 production while inducing regulatory T cells. In addition, vitamin D regulates epithelial cell integrity, innate immune responses, and the composition of the gut microbiota. Overall, vitamin D regulates multiple pathways that maintain gastrointestinal homeostasis. The data support improving vitamin D status in patients with inflammatory bowel diseases.
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U2 - 10.1177/1535370214523890
DO - 10.1177/1535370214523890
M3 - Article
C2 - 24668555
AN - SCOPUS:84910093083
SN - 1535-3702
VL - 239
SP - 1524
EP - 1530
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
IS - 11
ER -