TY - JOUR
T1 - Vitamin D intake is associated with dementia risk in the Washington Heights-Inwood Columbia Aging Project (WHICAP)
AU - Zhao, Chen
AU - Tsapanou, Angeliki
AU - Manly, Jennifer
AU - Schupf, Nicole
AU - Brickman, Adam M.
AU - Gu, Yian
N1 - Funding Information:
This manuscript has been reviewed by WHICAP investigators for scientific content and consistency of data interpretation with previous WHICAP Study publications. We acknowledge the WHICAP study participants and the WHICAP research and support staff for their contributions to this study. We additionally acknowledge Dr. Karen Marder for providing assistance in critical revision of the manuscript for intellectual content. This work was supported by the National Institute on Aging (NIA) through grant numbers PO1AG007232, R01AG037212, RF1AG054023, R00AG042483, and R01AG059013; National Institute of Neurological Disorders and Stroke (NINDS) through T32NS07153; and by the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant Number UL1TR001873; as well as the Charles and Ann Lee Brown Fellowship Fund.
Publisher Copyright:
© 2020 the Alzheimer's Association
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Introduction: Low vitamin D intake and low vitamin D circulating levels have been associated with increased risk for dementia. We aimed to examine the association between vitamin D intake and dementia in a multiethnic cohort. Methods: A longitudinal study of 1759 non-demented older (≥65 years) participants of the Washington Heights-Inwood Columbia Aging Project with follow-up visits and completed a food frequency questionnaire. Dementia was diagnosed by consensus using Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria. Cox hazard regression was performed. Results: During a mean follow-up of 5.8 years, 329 participants developed dementia. Participants with the highest tertile of vitamin D intake from food sources had decreased risk (hazard ratio [HR] 0.72, 95% confidence interval [CI] 0.54–0.97, P =.030) for dementia compared with those with the lowest tertile, adjusting for age, sex, race/ethnicity, education, apolipoprotein E (APOE)-ε4, physical activity, Mediterranean diet (MeDI) score, income, depression, hypertension, diabetes, cardiovascular disease, and smoking. Discussion: Higher vitamin D intake is associated with decreased risk of dementia in a multiethnic cohort.
AB - Introduction: Low vitamin D intake and low vitamin D circulating levels have been associated with increased risk for dementia. We aimed to examine the association between vitamin D intake and dementia in a multiethnic cohort. Methods: A longitudinal study of 1759 non-demented older (≥65 years) participants of the Washington Heights-Inwood Columbia Aging Project with follow-up visits and completed a food frequency questionnaire. Dementia was diagnosed by consensus using Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria. Cox hazard regression was performed. Results: During a mean follow-up of 5.8 years, 329 participants developed dementia. Participants with the highest tertile of vitamin D intake from food sources had decreased risk (hazard ratio [HR] 0.72, 95% confidence interval [CI] 0.54–0.97, P =.030) for dementia compared with those with the lowest tertile, adjusting for age, sex, race/ethnicity, education, apolipoprotein E (APOE)-ε4, physical activity, Mediterranean diet (MeDI) score, income, depression, hypertension, diabetes, cardiovascular disease, and smoking. Discussion: Higher vitamin D intake is associated with decreased risk of dementia in a multiethnic cohort.
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U2 - 10.1002/alz.12096
DO - 10.1002/alz.12096
M3 - Article
C2 - 32921000
AN - SCOPUS:85090847182
SN - 1552-5260
VL - 16
SP - 1393
EP - 1401
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 10
ER -
