TY - JOUR
T1 - Vitamin D status relates to reproductive outcome in women with polycystic ovary syndrome
T2 - Secondary analysis of a multicenter randomized controlled trial
AU - Pal, Lubna
AU - Zhang, Heping
AU - Williams, Joanne
AU - Santoro, Nanette F.
AU - Diamond, Michael P.
AU - Schlaff, William D.
AU - Coutifaris, Christos
AU - Carson, Sandra A.
AU - Steinkampf, Michael P.
AU - Carr, Bruce R.
AU - McGovern, Peter G.
AU - Cataldo, Nicholas A.
AU - Gosman, Gabriella G.
AU - Nestler, John E.
AU - Myers, Evan
AU - Legro, Richard S.
N1 - Funding Information:
Assistance of the National Institute of Child Health and Human Development (NICHD), the Reproductive Medicine Network, and the Protocol Subcommittee in making the database available is acknowledged. The PPCOS I was supported by NIH/ NICHDGrants U10 HD38998 (to W.D.S.), U10 HD055925 (to H.Z.), U10 HD39005 (to M.D.), U10 HD055936 (to G.C.), and U10 HD38992 (to R.S.L.), and grant support to University of Pittsburgh General Clinical Research Center (MO1RR00056)
PY - 2016/8
Y1 - 2016/8
N2 - Context: Experimental evidence supports a relevance of Vitamin D (VitD) for reproduction; however, data in humans are sparse and inconsistent. Objective: To assess the relationship of VitD status with ovulation induction (OI) outcomes in women with polycystic ovary syndrome (PCOS). Design: A retrospective cohort. Setting: Secondary analysis of randomized controlled trial data. Participants: Participants in the Pregnancy in PCOS I (PPCOS I) randomized controlled trial (nα540) met the National Institutes of Health diagnostic criteria for PCOS. Interventions: Serum 25OHD levels were measured in stored sera. Main Outcome Measures: Primary, live birth (LB); secondary, ovulation and pregnancy loss after OI. Results: Likelihood for LB was reduced by 44% for women if the 25OHD level was <30 ng/mL (<75 nmol/L; odds ratio [OR], 0.58 [0.35- 0.92]). Progressive improvement in the odds for LB was noted at thresholds of ≥38 ng/mL (≥95 nmol/L; OR, 1.42 [1.08 -1.8]), ≥40 ng/mL (≥100 nmol/L; OR, 1.51 [1.05-2.17]), and ≥45 ng/mL (≥112.5 nmol/L; OR, 4.46 [1.27-15.72]). On adjusted analyses, VitD status was an independent predictor of LB and ovulation after OI. Conclusions: In women with PCOS, serum 25OHD was an independent predictor of measures of reproductive success after OI. Our data identify reproductive thresholds for serum 25OHD that are higher than recommended for the nonpregnant population.
AB - Context: Experimental evidence supports a relevance of Vitamin D (VitD) for reproduction; however, data in humans are sparse and inconsistent. Objective: To assess the relationship of VitD status with ovulation induction (OI) outcomes in women with polycystic ovary syndrome (PCOS). Design: A retrospective cohort. Setting: Secondary analysis of randomized controlled trial data. Participants: Participants in the Pregnancy in PCOS I (PPCOS I) randomized controlled trial (nα540) met the National Institutes of Health diagnostic criteria for PCOS. Interventions: Serum 25OHD levels were measured in stored sera. Main Outcome Measures: Primary, live birth (LB); secondary, ovulation and pregnancy loss after OI. Results: Likelihood for LB was reduced by 44% for women if the 25OHD level was <30 ng/mL (<75 nmol/L; odds ratio [OR], 0.58 [0.35- 0.92]). Progressive improvement in the odds for LB was noted at thresholds of ≥38 ng/mL (≥95 nmol/L; OR, 1.42 [1.08 -1.8]), ≥40 ng/mL (≥100 nmol/L; OR, 1.51 [1.05-2.17]), and ≥45 ng/mL (≥112.5 nmol/L; OR, 4.46 [1.27-15.72]). On adjusted analyses, VitD status was an independent predictor of LB and ovulation after OI. Conclusions: In women with PCOS, serum 25OHD was an independent predictor of measures of reproductive success after OI. Our data identify reproductive thresholds for serum 25OHD that are higher than recommended for the nonpregnant population.
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U2 - 10.1210/jc.2015-4352
DO - 10.1210/jc.2015-4352
M3 - Article
C2 - 27186859
AN - SCOPUS:84984679633
SN - 0021-972X
VL - 101
SP - 3027
EP - 3035
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 8
ER -