Vitamin or mineral supplement intake and the risk of head and neck cancer: Pooled analysis in the INHANCE consortium

Qian Li, Shu Chun Chuang, Jose Eluf-Neto, Ana Menezes, Elena Matos, Sergio Koifman, Victor Wünsch-Filho, Leticia Fernandez, Alexander W. Daudt, Maria Paula Curado, Deborah M. Winn, Silvia Franceschi, Rolando Herrero, Xavier Castellsague, Hal Morgenstern, Zuo Feng Zhang, Philip Lazarus, Joshua Muscat, Michael McClean, Karl T. KelseyRichard B. Hayes, Mark P. Purdue, Stephen M. Schwartz, Chu Chen, Simone Benhamou, Andrew F. Olshan, Guopei Yu, Stimson Schantz, Gilles Ferro, Paul Brennan, Paolo Boffetta, Mia Hashibe

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


To investigate the potential role of vitamin or mineral supplementation on the risk of head and neck cancer (HNC), we analyzed individual-level pooled data from 12 case-control studies (7,002 HNC cases and 8,383 controls) participating in the International Head and Neck Cancer Epidemiology consortium. There were a total of 2,028 oral cavity cancer, 2,465 pharyngeal cancer, 874 unspecified oral/pharynx cancer, 1,329 laryngeal cancer and 306 overlapping HNC cases. Odds ratios (OR) and 95% confidence intervals (CIs) for self reported ever use of any vitamins, multivitamins, vitamin A, vitamin C, vitamin E, and calcium, beta-carotene, iron, selenium and zinc supplements were assessed. We further examined frequency, duration and cumulative exposure of each vitamin or mineral when possible and stratified by smoking and drinking status. All ORs were adjusted for age, sex, race/ethnicity, study center, education level, pack-years of smoking, frequency of alcohol drinking and fruit/vegetable intake. A decreased risk of HNC was observed with ever use of vitamin C (OR = 0.76, 95% CI = 0.59-0.96) and with ever use of calcium supplement (OR = 0.64, 95% CI = 0.42-0.97). The inverse association with HNC risk was also observed for 10 or more years of vitamin C use (OR = 0.72, 95% CI = 0.54-0.97) and more than 365 tablets of cumulative calcium intake (OR = 0.36, 95% CI = 0.16-0.83), but linear trends were not observed for the frequency or duration of any supplement intake. We did not observe any strong associations between vitamin or mineral supplement intake and the risk of HNC.

Original languageEnglish (US)
Pages (from-to)1686-1699
Number of pages14
JournalInternational Journal of Cancer
Issue number7
StatePublished - Oct 1 2012

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research


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