TY - JOUR
T1 - Vitamin or mineral supplement intake and the risk of head and neck cancer
T2 - Pooled analysis in the INHANCE consortium
AU - Li, Qian
AU - Chuang, Shu Chun
AU - Eluf-Neto, Jose
AU - Menezes, Ana
AU - Matos, Elena
AU - Koifman, Sergio
AU - Wünsch-Filho, Victor
AU - Fernandez, Leticia
AU - Daudt, Alexander W.
AU - Curado, Maria Paula
AU - Winn, Deborah M.
AU - Franceschi, Silvia
AU - Herrero, Rolando
AU - Castellsague, Xavier
AU - Morgenstern, Hal
AU - Zhang, Zuo Feng
AU - Lazarus, Philip
AU - Muscat, Joshua
AU - McClean, Michael
AU - Kelsey, Karl T.
AU - Hayes, Richard B.
AU - Purdue, Mark P.
AU - Schwartz, Stephen M.
AU - Chen, Chu
AU - Benhamou, Simone
AU - Olshan, Andrew F.
AU - Yu, Guopei
AU - Schantz, Stimson
AU - Ferro, Gilles
AU - Brennan, Paul
AU - Boffetta, Paolo
AU - Hashibe, Mia
PY - 2012/10/1
Y1 - 2012/10/1
N2 - To investigate the potential role of vitamin or mineral supplementation on the risk of head and neck cancer (HNC), we analyzed individual-level pooled data from 12 case-control studies (7,002 HNC cases and 8,383 controls) participating in the International Head and Neck Cancer Epidemiology consortium. There were a total of 2,028 oral cavity cancer, 2,465 pharyngeal cancer, 874 unspecified oral/pharynx cancer, 1,329 laryngeal cancer and 306 overlapping HNC cases. Odds ratios (OR) and 95% confidence intervals (CIs) for self reported ever use of any vitamins, multivitamins, vitamin A, vitamin C, vitamin E, and calcium, beta-carotene, iron, selenium and zinc supplements were assessed. We further examined frequency, duration and cumulative exposure of each vitamin or mineral when possible and stratified by smoking and drinking status. All ORs were adjusted for age, sex, race/ethnicity, study center, education level, pack-years of smoking, frequency of alcohol drinking and fruit/vegetable intake. A decreased risk of HNC was observed with ever use of vitamin C (OR = 0.76, 95% CI = 0.59-0.96) and with ever use of calcium supplement (OR = 0.64, 95% CI = 0.42-0.97). The inverse association with HNC risk was also observed for 10 or more years of vitamin C use (OR = 0.72, 95% CI = 0.54-0.97) and more than 365 tablets of cumulative calcium intake (OR = 0.36, 95% CI = 0.16-0.83), but linear trends were not observed for the frequency or duration of any supplement intake. We did not observe any strong associations between vitamin or mineral supplement intake and the risk of HNC.
AB - To investigate the potential role of vitamin or mineral supplementation on the risk of head and neck cancer (HNC), we analyzed individual-level pooled data from 12 case-control studies (7,002 HNC cases and 8,383 controls) participating in the International Head and Neck Cancer Epidemiology consortium. There were a total of 2,028 oral cavity cancer, 2,465 pharyngeal cancer, 874 unspecified oral/pharynx cancer, 1,329 laryngeal cancer and 306 overlapping HNC cases. Odds ratios (OR) and 95% confidence intervals (CIs) for self reported ever use of any vitamins, multivitamins, vitamin A, vitamin C, vitamin E, and calcium, beta-carotene, iron, selenium and zinc supplements were assessed. We further examined frequency, duration and cumulative exposure of each vitamin or mineral when possible and stratified by smoking and drinking status. All ORs were adjusted for age, sex, race/ethnicity, study center, education level, pack-years of smoking, frequency of alcohol drinking and fruit/vegetable intake. A decreased risk of HNC was observed with ever use of vitamin C (OR = 0.76, 95% CI = 0.59-0.96) and with ever use of calcium supplement (OR = 0.64, 95% CI = 0.42-0.97). The inverse association with HNC risk was also observed for 10 or more years of vitamin C use (OR = 0.72, 95% CI = 0.54-0.97) and more than 365 tablets of cumulative calcium intake (OR = 0.36, 95% CI = 0.16-0.83), but linear trends were not observed for the frequency or duration of any supplement intake. We did not observe any strong associations between vitamin or mineral supplement intake and the risk of HNC.
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U2 - 10.1002/ijc.27405
DO - 10.1002/ijc.27405
M3 - Article
C2 - 22173631
AN - SCOPUS:84864454551
SN - 0020-7136
VL - 131
SP - 1686
EP - 1699
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 7
ER -