Water movement in the rabbit eye

Hong Ming Cheng; Kenneth K. Kwong; Sonya Dixon; George Tanaka; Jing Xiong; Gregory Moore; David A. Chesler

doi:10.1016/0014-4835(91)90098-Y

Water movement in the rabbit eye

Hong Ming Cheng
, Kenneth K. Kwong
, Sonya Dixon
, George Tanaka
, Jing Xiong
, Gregory Moore
, David A. Chesler

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The intraocular distribution of topically applied D₂O was quantified using deuterium nuclear magnetic resonance (NMR) spectroscopy, D₂O appeared in all tissues with the highest concentration in the aqueous humor (1·2 m); however, it rapidly dissipated from the eye. Surface coil NMR spectroscopy on D₂O-treated eyes in vivo showed that the flow pattern was best described by a single exponential decay plus a constant. This suggests that the D₂O flow consisted of a flow component representing vascular circulation (with a flow rate constant of 0·101 min^-1), and a reservoir-like component. Topical D₂O in conjunction with the surface-coil NMR technique can be used to examine the movement of water in the anterior segment of the living eye.

Original language	English (US)
Pages (from-to)	337-339
Number of pages	3
Journal	Experimental Eye Research
Volume	52
Issue number	3
DOIs	https://doi.org/10.1016/0014-4835(91)90098-Y
State	Published - Mar 1991

All Science Journal Classification (ASJC) codes

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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10.1016/0014-4835(91)90098-Y

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@article{48c99ce348d9468d9679f473bd21c58f,

title = "Water movement in the rabbit eye",

abstract = "The intraocular distribution of topically applied D2O was quantified using deuterium nuclear magnetic resonance (NMR) spectroscopy, D2O appeared in all tissues with the highest concentration in the aqueous humor (1·2 m); however, it rapidly dissipated from the eye. Surface coil NMR spectroscopy on D2O-treated eyes in vivo showed that the flow pattern was best described by a single exponential decay plus a constant. This suggests that the D2O flow consisted of a flow component representing vascular circulation (with a flow rate constant of 0·101 min-1), and a reservoir-like component. Topical D2O in conjunction with the surface-coil NMR technique can be used to examine the movement of water in the anterior segment of the living eye.",

author = "Cheng, \{Hong Ming\} and Kwong, \{Kenneth K.\} and Sonya Dixon and George Tanaka and Jing Xiong and Gregory Moore and Chesler, \{David A.\}",

year = "1991",

month = mar,

doi = "10.1016/0014-4835(91)90098-Y",

language = "English (US)",

volume = "52",

pages = "337--339",

journal = "Experimental Eye Research",

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TY - JOUR

T1 - Water movement in the rabbit eye

AU - Cheng, Hong Ming

AU - Kwong, Kenneth K.

AU - Dixon, Sonya

AU - Tanaka, George

AU - Xiong, Jing

AU - Moore, Gregory

AU - Chesler, David A.

PY - 1991/3

Y1 - 1991/3

N2 - The intraocular distribution of topically applied D2O was quantified using deuterium nuclear magnetic resonance (NMR) spectroscopy, D2O appeared in all tissues with the highest concentration in the aqueous humor (1·2 m); however, it rapidly dissipated from the eye. Surface coil NMR spectroscopy on D2O-treated eyes in vivo showed that the flow pattern was best described by a single exponential decay plus a constant. This suggests that the D2O flow consisted of a flow component representing vascular circulation (with a flow rate constant of 0·101 min-1), and a reservoir-like component. Topical D2O in conjunction with the surface-coil NMR technique can be used to examine the movement of water in the anterior segment of the living eye.

AB - The intraocular distribution of topically applied D2O was quantified using deuterium nuclear magnetic resonance (NMR) spectroscopy, D2O appeared in all tissues with the highest concentration in the aqueous humor (1·2 m); however, it rapidly dissipated from the eye. Surface coil NMR spectroscopy on D2O-treated eyes in vivo showed that the flow pattern was best described by a single exponential decay plus a constant. This suggests that the D2O flow consisted of a flow component representing vascular circulation (with a flow rate constant of 0·101 min-1), and a reservoir-like component. Topical D2O in conjunction with the surface-coil NMR technique can be used to examine the movement of water in the anterior segment of the living eye.

UR - https://www.scopus.com/pages/publications/0026096925

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DO - 10.1016/0014-4835(91)90098-Y

M3 - Article

C2 - 2015863

AN - SCOPUS:0026096925

SN - 0014-4835

VL - 52

SP - 337

EP - 339

JO - Experimental Eye Research

JF - Experimental Eye Research

IS - 3

ER -

Water movement in the rabbit eye

Abstract

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