When targeted therapy for cancer leads to ICU admission. RETRO-TARGETICU multicentric study

Anne Pascale Meert, Anne Claire Toffart, Muriel Picard, Paul Jaubert, Aude Gibelin, Philippe Bauer, Djamel Mokart, Andry Van De Louw, Stefan Hatzl, Gabriel Moreno-Gonzales, Gaelle Rousseau-Bussac, Fabrice Bruneel, Luca Montini, Anne Sophie Moreau, Dorothée Carpentier, Amelie Seguin, Pleun Hemelaar, Elie Azoulay, Virginie Lemiale

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Purpose: To study prevalence of targeted therapy (TT)-related adverse events requiring ICU admission in solid tumor patients. Methods: Retrospective multicenter study from the Nine-i research group. Adult patients who received TT for solid tumor within 3 months prior to ICU admission were included. Patients admitted for TT-related adverse event were compared to those admitted for other reasons. Results: In total, 140 patients, median age of 63 (52–69) years were included. Primary cancer site was mostly digestive (n = 27, 19%), kidney (n = 27, 19%), breast (n = 24, 17%), and lung (n = 20, 14%). Targeted therapy was anti-VEGF/VEGFR for 27% (n = 38) patients, anti-EGFR for 22% (n = 31) patients, anti-HER2 for 14% (n = 20) patients and anti-BRAF for 9% (n = 5) patients. ICU admission was related to TT adverse events for 30 (21%) patients. The most frequent complications were interstitial pneumonia (n = 7), cardiac failure (n = 5), anaphylaxis (n = 4) and bleeding (n = 4). At ICU admission, no significant difference was found between patients admitted for a TT-related adverse event and the other patients. One-month survival rate was higher in patients admitted for TT adverse event (OR = 5.733 [2.031–16.182] P < 0.001). Conclusions: Adverse events related to targeted therapy accounted for 20% of ICU admission in our population and carried a 16% one-month mortality. Outcome was associated with admission for TT related to adverse event, breast cancer and good performance status.

Original languageEnglish (US)
Pages (from-to)916-924
Number of pages9
JournalBulletin du Cancer
Issue number9
StatePublished - Sep 2022

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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