TY - GEN
T1 - Whole-cell biocatalysis in biphasic media for oxidation of naphthalene
AU - Janardhan Garikipati, S. V.B.
AU - Peeples, Tonya L.
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Biocatalysis involves the use of enzymes to perform stereo- and enatio-specific reactions producing valuable products in an environmentally benign way. However, the hydrophobic nature of most of the substrates affects the productivity due to poor solubility in aqueous solutions and high toxicity to cells expressing the biocatalyst. These drawbacks can be eliminated by using biphasic media, where a second phase of organic solvent serves as a reservoir of substrate and helps in extracting the products in-situ. The use of biocatalysis in biphasic media is applied to oxidation of napthalane to produce either 1-naphthol or 1,2-naphthalene dihydrodiol.
AB - Biocatalysis involves the use of enzymes to perform stereo- and enatio-specific reactions producing valuable products in an environmentally benign way. However, the hydrophobic nature of most of the substrates affects the productivity due to poor solubility in aqueous solutions and high toxicity to cells expressing the biocatalyst. These drawbacks can be eliminated by using biphasic media, where a second phase of organic solvent serves as a reservoir of substrate and helps in extracting the products in-situ. The use of biocatalysis in biphasic media is applied to oxidation of napthalane to produce either 1-naphthol or 1,2-naphthalene dihydrodiol.
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M3 - Conference contribution
AN - SCOPUS:77955644644
SN - 9780841269859
T3 - ACS National Meeting Book of Abstracts
BT - American Chemical Society - 235th National Meeting, Abstracts of Scientific Papers
T2 - 235th National Meeting of the American Chemical Society, ACS 2008
Y2 - 6 April 2008 through 10 April 2008
ER -