Whole-genome sequence of a varicella-zoster strain from an immunocompetent pediatric patient with severe herpes zoster

Alejandro Ortigas-Vasquez; Braylen V. Washington; Mackenzie Shipley; David C. Bloom; Charles Grose; Moriah L. Szpara

doi:10.1128/mra.01123-25

Whole-genome sequence of a varicella-zoster strain from an immunocompetent pediatric patient with severe herpes zoster

Alejandro Ortigas-Vasquez
, Braylen V. Washington
, Mackenzie Shipley
, David C. Bloom
, Charles Grose
, Moriah L. Szpara

Research output: Contribution to journal › Article › peer-review

Abstract

We report the complete genome sequence of CGI, a strain of varicella-zoster virus (VZV) isolated from a 3-year-old immunocompetent patient with severe herpes zoster. The isolated strain exhibits an ORF62 genotype characteristic of vOka, in addition to a wild-type ORF0 gene and a novel methionine to valine substitution in ORF58.

Original language	English (US)
Article number	e01123-25
Journal	Microbiology Resource Announcements
Volume	15
Issue number	6
DOIs	https://doi.org/10.1128/mra.01123-25
State	Published - Jun 2026

All Science Journal Classification (ASJC) codes

Molecular Biology
Immunology and Microbiology (miscellaneous)
Genetics

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10.1128/mra.01123-25

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title = "Whole-genome sequence of a varicella-zoster strain from an immunocompetent pediatric patient with severe herpes zoster",

abstract = "We report the complete genome sequence of CGI, a strain of varicella-zoster virus (VZV) isolated from a 3-year-old immunocompetent patient with severe herpes zoster. The isolated strain exhibits an ORF62 genotype characteristic of vOka, in addition to a wild-type ORF0 gene and a novel methionine to valine substitution in ORF58.",

author = "Alejandro Ortigas-Vasquez and Washington, \{Braylen V.\} and Mackenzie Shipley and Bloom, \{David C.\} and Charles Grose and Szpara, \{Moriah L.\}",

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AU - Ortigas-Vasquez, Alejandro

AU - Washington, Braylen V.

AU - Shipley, Mackenzie

AU - Bloom, David C.

AU - Grose, Charles

AU - Szpara, Moriah L.

PY - 2026/6

Y1 - 2026/6

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AB - We report the complete genome sequence of CGI, a strain of varicella-zoster virus (VZV) isolated from a 3-year-old immunocompetent patient with severe herpes zoster. The isolated strain exhibits an ORF62 genotype characteristic of vOka, in addition to a wild-type ORF0 gene and a novel methionine to valine substitution in ORF58.

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DO - 10.1128/mra.01123-25

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AN - SCOPUS:105041832782

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ER -

Whole-genome sequence of a varicella-zoster strain from an immunocompetent pediatric patient with severe herpes zoster

Abstract

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