Why inhaling salt water changes what we exhale

Wiwik Watanabe; Matthew Thomas; Robert Clarke; Alexander M. Klibanov; Robert Langer; Jeffrey Katstra; Gerald G. Fuller; Lester C. Griel; Jennifer Fiegel; David Edwards

doi:10.1016/j.jcis.2006.11.017

Why inhaling salt water changes what we exhale

Wiwik Watanabe, Matthew Thomas, Robert Clarke, Alexander M. Klibanov, Robert Langer, Jeffrey Katstra, Gerald G. Fuller, Lester C. Griel, Jennifer Fiegel, David Edwards

Veterinary and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

We find that inhaling salt water diminishes subsequently exhaled biomaterial in man and animals due to reversible stabilization of the airway lining fluid (ALF)/air interface as a novel potential means for control of the spread of airborne infectious disease. The mechanism of this phenomenon relates to charge shielding of mucin or mucin-like macromolecules that consequently undergo gelation; this gelation alters the physical properties of the ALF surface and reduces its breakup. Cations in the nebulized solution and apparent surface viscoelasticity of the ALF (more than any other ALF intrinsic physical property) appear to be responsible for the reduced tendency of the ALF to disintegrate into very small droplets. We confirm these effects in vivo and show their reversibility through nebulization of saline solutions to anesthetized bull calves.

Original language	English (US)
Pages (from-to)	71-78
Number of pages	8
Journal	Journal of Colloid And Interface Science
Volume	307
Issue number	1
DOIs	https://doi.org/10.1016/j.jcis.2006.11.017
State	Published - Mar 1 2007

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Biomaterials
Surfaces, Coatings and Films
Colloid and Surface Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jcis.2006.11.017

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abstract = "We find that inhaling salt water diminishes subsequently exhaled biomaterial in man and animals due to reversible stabilization of the airway lining fluid (ALF)/air interface as a novel potential means for control of the spread of airborne infectious disease. The mechanism of this phenomenon relates to charge shielding of mucin or mucin-like macromolecules that consequently undergo gelation; this gelation alters the physical properties of the ALF surface and reduces its breakup. Cations in the nebulized solution and apparent surface viscoelasticity of the ALF (more than any other ALF intrinsic physical property) appear to be responsible for the reduced tendency of the ALF to disintegrate into very small droplets. We confirm these effects in vivo and show their reversibility through nebulization of saline solutions to anesthetized bull calves.",

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AU - Watanabe, Wiwik

AU - Thomas, Matthew

AU - Clarke, Robert

AU - Klibanov, Alexander M.

AU - Langer, Robert

AU - Katstra, Jeffrey

AU - Fuller, Gerald G.

AU - Griel, Lester C.

AU - Fiegel, Jennifer

AU - Edwards, David

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Why inhaling salt water changes what we exhale

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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