Why is DNA damage signaling so complicated? Chaos and molecular signaling

Betsy M. Sutherland; Paula V. Bennett; Emily Weinert; Olga Sidorkina; Jacques Laval

doi:10.1002/em.1063

Why is DNA damage signaling so complicated? Chaos and molecular signaling

Betsy M. Sutherland, Paula V. Bennett, Emily Weinert, Olga Sidorkina, Jacques Laval

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Molecular signaling in eukaryotic cells is accomplished by complex and redundant pathways converging on key molecules that are allosterically controlled by a limited number of signaling proteins. The p53-signaling pathway is an example of a complicated sequence of signals produced in response to DNA damage. This pattern of signaling may arise from chance occurrences at the origin of life and the necessities imposed on a nanomolar system. From this viewpoint, chaos theory may explain the origin, complexity, and convergence of these pathways.

Original language	English (US)
Pages (from-to)	132-134
Number of pages	3
Journal	Environmental and Molecular Mutagenesis
Volume	38
Issue number	2-3
DOIs	https://doi.org/10.1002/em.1063
State	Published - 2001

All Science Journal Classification (ASJC) codes

Epidemiology
Genetics(clinical)
Health, Toxicology and Mutagenesis

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abstract = "Molecular signaling in eukaryotic cells is accomplished by complex and redundant pathways converging on key molecules that are allosterically controlled by a limited number of signaling proteins. The p53-signaling pathway is an example of a complicated sequence of signals produced in response to DNA damage. This pattern of signaling may arise from chance occurrences at the origin of life and the necessities imposed on a nanomolar system. From this viewpoint, chaos theory may explain the origin, complexity, and convergence of these pathways.",

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AU - Bennett, Paula V.

AU - Weinert, Emily

AU - Sidorkina, Olga

AU - Laval, Jacques

PY - 2001

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AB - Molecular signaling in eukaryotic cells is accomplished by complex and redundant pathways converging on key molecules that are allosterically controlled by a limited number of signaling proteins. The p53-signaling pathway is an example of a complicated sequence of signals produced in response to DNA damage. This pattern of signaling may arise from chance occurrences at the origin of life and the necessities imposed on a nanomolar system. From this viewpoint, chaos theory may explain the origin, complexity, and convergence of these pathways.

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JO - Environmental and Molecular Mutagenesis

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Why is DNA damage signaling so complicated? Chaos and molecular signaling

Abstract

All Science Journal Classification (ASJC) codes

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