Why is DNA damage signaling so complicated? Chaos and molecular signaling

Betsy M. Sutherland, Paula V. Bennett, Emily Weinert, Olga Sidorkina, Jacques Laval

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Molecular signaling in eukaryotic cells is accomplished by complex and redundant pathways converging on key molecules that are allosterically controlled by a limited number of signaling proteins. The p53-signaling pathway is an example of a complicated sequence of signals produced in response to DNA damage. This pattern of signaling may arise from chance occurrences at the origin of life and the necessities imposed on a nanomolar system. From this viewpoint, chaos theory may explain the origin, complexity, and convergence of these pathways.

Original languageEnglish (US)
Pages (from-to)132-134
Number of pages3
JournalEnvironmental and Molecular Mutagenesis
Issue number2-3
StatePublished - 2001

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Genetics(clinical)
  • Health, Toxicology and Mutagenesis


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