Abstract
A molecular wire is used to connect two proteins through their physiologically relevant redox cofactors to facilitate direct electron transfer. Photosystem I (PS I) and an [FeFe]-hydrogenase (H2ase) serve as the test bed for this new technology. By tethering a photosensitizer with a hydrogen-evolving catalyst, attached by Fe-S coordination bonds between the FB iron-sulfur cluster of PS I and the distal iron-sulfur cluster of H 2ase, we assayed electron transfer between the two components via light-induced hydrogen generation. These hydrogen-producing nanoconstructs self-assemble when the PS I variant, the H2ase variant, and the molecular wire are combined.
Original language | English (US) |
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Pages (from-to) | 10264-10266 |
Number of pages | 3 |
Journal | Biochemistry |
Volume | 49 |
Issue number | 48 |
DOIs | |
State | Published - Dec 7 2010 |
All Science Journal Classification (ASJC) codes
- Biochemistry