TY - JOUR
T1 - Wolbachia pipientis
T2 - An expanding bag of tricks to explore for disease control
AU - Cook, Peter E.
AU - McGraw, Elizabeth A.
N1 - Funding Information:
The authors wish to acknowledge Scott O’Neill and four anonymous reviewers for critical comment on the manuscript and the Foundation for the National Institutes of Health through the Grand Challenges in Global Health Initiative of the Bill and Melinda Gates Foundation, the National Health and Medical Research Council, Australia and the Queensland Government for grant support.
PY - 2010/8
Y1 - 2010/8
N2 - Wolbachia pipientis are maternally inherited, endosymbiotic bacteria that are widespread among insects. Two recent studies have demonstrated that Wolbachia inhibits the ability of medically significant pathogens, including filarial nematodes, dengue virus and Plasmodium to form infections in the mosquito vector, Aedes aegypti. We highlight the added value of these traits for Wolbachia based biocontrol strategies and evaluate the evidence for the idea that the insect immune response is responsible for the pathogen inhibition.
AB - Wolbachia pipientis are maternally inherited, endosymbiotic bacteria that are widespread among insects. Two recent studies have demonstrated that Wolbachia inhibits the ability of medically significant pathogens, including filarial nematodes, dengue virus and Plasmodium to form infections in the mosquito vector, Aedes aegypti. We highlight the added value of these traits for Wolbachia based biocontrol strategies and evaluate the evidence for the idea that the insect immune response is responsible for the pathogen inhibition.
UR - http://www.scopus.com/inward/record.url?scp=77955057410&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955057410&partnerID=8YFLogxK
U2 - 10.1016/j.pt.2010.05.006
DO - 10.1016/j.pt.2010.05.006
M3 - Short survey
C2 - 20647151
AN - SCOPUS:77955057410
SN - 1471-4922
VL - 26
SP - 373
EP - 375
JO - Trends in Parasitology
JF - Trends in Parasitology
IS - 8
ER -
