WT1/EGR1-mediated control of STIM1 expression and function in cancer cells

Michael F. Ritchie, Yandong Zhou, Jonathan Soboloff

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


There have been numerous publications linking Ca2+ signaling and cancer, however, a clear explanation for this link has remained elusive. We recently identified the oncogenes/tumor suppressors Wilms Tumor Suppressor 1 (WT1) and Early Growth Response 1 (EGR1) as regulators of the expression of STIM1, an essential regulator of Ca2+ entry in non-excitable cells. The current review focuses on the literature defining both differential Ca 2+ signaling and WT1/EGR1 expression patterns in 5 specific cancer subtypes: Acute Myeloid Leukemia, Wilms Tumor, breast cancer, glioblastoma and prostate cancer. For each tumortype, we have assessed how specific changes in WT1 and EGR1 expression might contribute to aberrant Ca2+ homeostasis as well as the therapeutic potential of these observations.

Original languageEnglish (US)
Pages (from-to)2402-2415
Number of pages14
JournalFrontiers in Bioscience
Issue number7
StatePublished - Jun 1 2011

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology


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