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X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein

  • Vadim Molodtsov
  • , Paul R. Fleming
  • , Charles J. Eyermann
  • , Andrew D. Ferguson
  • , Melinda A. Foulk
  • , David C. McKinney
  • , Craig E. Masse
  • , Ed T. Buurman
  • , Katsuhiko S. Murakami

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Biochemistry, Genetics and Molecular Biology

Pharmacology, Toxicology and Pharmaceutical Science