TY - GEN
T1 - Y-cut quartz resonator based calorimetric sensor
AU - Goyal, Abhijat
AU - Zhang, Yuyan
AU - Tadigadapa, Srinivas
PY - 2005/12/1
Y1 - 2005/12/1
N2 - Monitoring of chemical and biochemical reactions such as neutralization reactions, antibody-antigen binding events, and enzyme catalyzed reactions, etc. can be achieved using calorimetric (bio)chemical sensors. A calorimeter array consisting of a thin film thermopile as temperature sensor integrated with microfluidic channels has already been demonstrated recently. In order to improve the sensitivity of the device, a temperature sensing element based on Y-cut quartz is proposed. The temperature-frequency calibration of a 125 μm thick Y-cut quartz resonator has been experimentally measured in the 22-60°C temperature range. Preliminary measurements of the neutralization reaction have been performed using the resonator to demonstrate the potential of the device for calorimetric sensing applications. It can be concluded that upon optimization of the device for thermal performance and appropriate compensation of mass loading and viscoelastic effects using a differential arrangement, ultrasensitive calorimetric measurements can be performed using such a device.
AB - Monitoring of chemical and biochemical reactions such as neutralization reactions, antibody-antigen binding events, and enzyme catalyzed reactions, etc. can be achieved using calorimetric (bio)chemical sensors. A calorimeter array consisting of a thin film thermopile as temperature sensor integrated with microfluidic channels has already been demonstrated recently. In order to improve the sensitivity of the device, a temperature sensing element based on Y-cut quartz is proposed. The temperature-frequency calibration of a 125 μm thick Y-cut quartz resonator has been experimentally measured in the 22-60°C temperature range. Preliminary measurements of the neutralization reaction have been performed using the resonator to demonstrate the potential of the device for calorimetric sensing applications. It can be concluded that upon optimization of the device for thermal performance and appropriate compensation of mass loading and viscoelastic effects using a differential arrangement, ultrasensitive calorimetric measurements can be performed using such a device.
UR - http://www.scopus.com/inward/record.url?scp=33847255574&partnerID=8YFLogxK
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U2 - 10.1109/ICSENS.2005.1597931
DO - 10.1109/ICSENS.2005.1597931
M3 - Conference contribution
AN - SCOPUS:33847255574
SN - 0780390563
SN - 9780780390560
T3 - Proceedings of IEEE Sensors
SP - 1241
EP - 1244
BT - Proceedings of the Fourth IEEE Conference on Sensors 2005
T2 - Fourth IEEE Conference on Sensors 2005
Y2 - 31 October 2005 through 3 November 2005
ER -