ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

Xianjiang Lan; Ren Ren; Ruopeng Feng; Lana C. Ly; Yemin Lan; Zhe Zhang; Nicholas Aboreden; Kunhua Qin; John R. Horton; Jeremy D. Grevet; Thiyagaraj Mayuranathan; Osheiza Abdulmalik; Cheryl A. Keller; Belinda Giardine; Ross C. Hardison; Merlin Crossley; Mitchell J. Weiss; Xiaodong Cheng; Junwei Shi; Gerd A. Blobel

doi:10.1016/j.molcel.2020.11.006

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

Xianjiang Lan
, Ren Ren
, Ruopeng Feng
, Lana C. Ly
, Yemin Lan
, Zhe Zhang
, Nicholas Aboreden
, Kunhua Qin
, John R. Horton
, Jeremy D. Grevet
, Thiyagaraj Mayuranathan
, Osheiza Abdulmalik
, Cheryl A. Keller
, Belinda Giardine
, Ross C. Hardison
, Merlin Crossley
, Mitchell J. Weiss
, Xiaodong Cheng
, Junwei Shi
, Gerd A. Blobel

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

Lan et al. show that the transcription factor ZNF410 has a single direct target gene, the NuRD component CHD4, through which it silences the fetal-type β-globin genes in adult erythroid cells. The exquisite specificity of ZNF410 could be exploited therapeutically for treatment of hemoglobinopathies.

Original language	English (US)
Pages (from-to)	239-254.e8
Journal	Molecular cell
Volume	81
Issue number	2
DOIs	https://doi.org/10.1016/j.molcel.2020.11.006
State	Published - Jan 21 2021

All Science Journal Classification (ASJC) codes

Molecular Biology
Cell Biology

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10.1016/j.molcel.2020.11.006

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Lan, X., Ren, R., Feng, R., Ly, L. C., Lan, Y., Zhang, Z., Aboreden, N., Qin, K., Horton, J. R., Grevet, J. D., Mayuranathan, T., Abdulmalik, O., Keller, C. A., Giardine, B., Hardison, R. C., Crossley, M., Weiss, M. J., Cheng, X., Shi, J., & Blobel, G. A. (2021). ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression. Molecular cell, 81(2), 239-254.e8. https://doi.org/10.1016/j.molcel.2020.11.006

@article{ba07391894fd4003841c726a8dedeee9,

title = "ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression",

abstract = "Lan et al. show that the transcription factor ZNF410 has a single direct target gene, the NuRD component CHD4, through which it silences the fetal-type β-globin genes in adult erythroid cells. The exquisite specificity of ZNF410 could be exploited therapeutically for treatment of hemoglobinopathies.",

author = "Xianjiang Lan and Ren Ren and Ruopeng Feng and Ly, \{Lana C.\} and Yemin Lan and Zhe Zhang and Nicholas Aboreden and Kunhua Qin and Horton, \{John R.\} and Grevet, \{Jeremy D.\} and Thiyagaraj Mayuranathan and Osheiza Abdulmalik and Keller, \{Cheryl A.\} and Belinda Giardine and Hardison, \{Ross C.\} and Merlin Crossley and Weiss, \{Mitchell J.\} and Xiaodong Cheng and Junwei Shi and Blobel, \{Gerd A.\}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2021",

month = jan,

day = "21",

doi = "10.1016/j.molcel.2020.11.006",

language = "English (US)",

volume = "81",

pages = "239--254.e8",

journal = "Molecular cell",

issn = "1097-2765",

publisher = "Cell Press",

number = "2",

}

Lan, X, Ren, R, Feng, R, Ly, LC, Lan, Y, Zhang, Z, Aboreden, N, Qin, K, Horton, JR, Grevet, JD, Mayuranathan, T, Abdulmalik, O, Keller, CA, Giardine, B, Hardison, RC, Crossley, M, Weiss, MJ, Cheng, X, Shi, J & Blobel, GA 2021, 'ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression', Molecular cell, vol. 81, no. 2, pp. 239-254.e8. https://doi.org/10.1016/j.molcel.2020.11.006

TY - JOUR

T1 - ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

AU - Lan, Xianjiang

AU - Ren, Ren

AU - Feng, Ruopeng

AU - Ly, Lana C.

AU - Lan, Yemin

AU - Zhang, Zhe

AU - Aboreden, Nicholas

AU - Qin, Kunhua

AU - Horton, John R.

AU - Grevet, Jeremy D.

AU - Mayuranathan, Thiyagaraj

AU - Abdulmalik, Osheiza

AU - Keller, Cheryl A.

AU - Giardine, Belinda

AU - Hardison, Ross C.

AU - Crossley, Merlin

AU - Weiss, Mitchell J.

AU - Cheng, Xiaodong

AU - Shi, Junwei

AU - Blobel, Gerd A.

PY - 2021/1/21

Y1 - 2021/1/21

N2 - Lan et al. show that the transcription factor ZNF410 has a single direct target gene, the NuRD component CHD4, through which it silences the fetal-type β-globin genes in adult erythroid cells. The exquisite specificity of ZNF410 could be exploited therapeutically for treatment of hemoglobinopathies.

AB - Lan et al. show that the transcription factor ZNF410 has a single direct target gene, the NuRD component CHD4, through which it silences the fetal-type β-globin genes in adult erythroid cells. The exquisite specificity of ZNF410 could be exploited therapeutically for treatment of hemoglobinopathies.

UR - https://www.scopus.com/pages/publications/85098119358

UR - https://www.scopus.com/pages/publications/85098119358#tab=citedBy

U2 - 10.1016/j.molcel.2020.11.006

DO - 10.1016/j.molcel.2020.11.006

M3 - Article

C2 - 33301730

AN - SCOPUS:85098119358

SN - 1097-2765

VL - 81

SP - 239-254.e8

JO - Molecular cell

JF - Molecular cell

IS - 2

ER -

ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

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