TY - JOUR
T1 - Zoster incidence in human immunodeficiency virus-infected hemophiliacs and homosexual men, 1984-1997
AU - Engels, Eric A.
AU - Rosenberg, Philip S.
AU - Biggar, Robert J.
AU - Gail, Mitchell
AU - Goedert, James J.
AU - O'Brien, Thomas R.
AU - Rabkin, Charles
AU - Kroner, Barbara L.
AU - Wilson, Susan L.
AU - Aledort, Louis M.
AU - Seremetes, Stephanie
AU - Eyster, M. Elaine
AU - Di Michele, Donna
AU - Hilgartner, Maragaret W.
AU - Konkle, B. Barbara
AU - Blatt, P. Phillip
AU - White, Gilbert C.
AU - Cohen, Alan R.
AU - Angiolillo, Anne L.
AU - Luban, Naomi
AU - Kessler, Craig M.
AU - Lederman, Michael M.
AU - Leissinger, Cindy
AU - Manco-Johnson, Marilyn
AU - Hoots, W. Keith
AU - De Moerloose, Philippe
AU - Hatzakis, Angelos
AU - Karafoulidou, A. Anastasia
AU - Mandalaki, Titika
AU - Schramm, Wolfgang
AU - Eichinger, Sabine
N1 - Funding Information:
This study was approved by institutional review committees at the National Cancer Institute and participating centers. Study subjects gave informed consent. a Cohort study investigators and institutions are listed after the text.
Funding Information:
National Cancer Institute, Rockville, MD: Eric A. Engels, Mitchell Gail, James J. Goedert, Thomas R. O’Brien, Charles Rabkin, Philip S. Rosenberg; Research Triangle Institute, Rockville, MD: Barbara L. Kroner, Susan E. Wilson; Mount Sinai Medical Center, New York City: Louis M. Aledort, Stephanie Seremetes; Pennsylvania State University School of Medicine, Hershey: M. Elaine Eyster; Cornell University Medical Center, New York City: Donna Di Michele, Maragaret W. Hilgartner; Cardeza Foundation Hemophilia Center, Philadelphia: Barbara Konkle; Christiana Hospital, Newark, DE: Phil-lip Blatt; University of North Carolina, Chapel Hill: Gilbert C. White, II; Children’s Hospital of Philadelphia: Alan R. Cohen; Children’s Hospital National Medical Center, Washington, DC: Anne L. Angiolillo, Naomi Luban; Georgetown University Medical Center, Washington, DC: Craig M. Kessler; Case Western Reserve University, Cleveland: Michael M. Lederman; Tulane University Medical School, New Orleans: Cindy Leis- singer; University of Colorado, Denver: Marilyn Manco-Johnson; University of Texas Health Science Center, Houston: W. Keith Hoots; Hospital Cantonal Universitaire, Geneva, Switzerland: Philippe de Moerloose; Athens University Medical School and Laikon General Hospital, Athens, Greece: Angelos Hatzakis, Anastasia Karafoulidou, Titika Mandalaki; Univer-sität München, Munich, Germany: Wolfgang Schramm; University of Vienna, Austria: Sabine Eichinger.
PY - 1999
Y1 - 1999
N2 - Zoster is an important clinical problem for human immunodeficiency virus type 1 (HIV)-infected patients. Risk factors for zoster and trends in incidence in HIV-infected hemophiliacs and homosexual men (n = 1218) were examined. From 1984 to 1997, 174 zoster cases were identified (average yearly incidence, 2.5%). Prior zoster episodes were associated with increased risk for a subsequent episode (relative risk [RR], 4.30; 95% confidence interval [CI], 3.11-5.95). Among hemophiliacs, children and adolescents had the highest zoster risk, and zoster risk declined with age (RR, 0.80 per decade; 95% CI, 0.68-0.93). These findings suggest that HIV-infected persons do not produce or maintain adequate booster responses after varicella zoster virus exposure. Zoster risk was relatively constant when CD4 cell counts >200 cells/mm3 but increased steeply below this level. During the 14 years of follow-up, zoster incidence declined 9% per year. This trend occurred despite decreasing CD4 cell counts and was unexplained by zidovudine or acyclovir use.
AB - Zoster is an important clinical problem for human immunodeficiency virus type 1 (HIV)-infected patients. Risk factors for zoster and trends in incidence in HIV-infected hemophiliacs and homosexual men (n = 1218) were examined. From 1984 to 1997, 174 zoster cases were identified (average yearly incidence, 2.5%). Prior zoster episodes were associated with increased risk for a subsequent episode (relative risk [RR], 4.30; 95% confidence interval [CI], 3.11-5.95). Among hemophiliacs, children and adolescents had the highest zoster risk, and zoster risk declined with age (RR, 0.80 per decade; 95% CI, 0.68-0.93). These findings suggest that HIV-infected persons do not produce or maintain adequate booster responses after varicella zoster virus exposure. Zoster risk was relatively constant when CD4 cell counts >200 cells/mm3 but increased steeply below this level. During the 14 years of follow-up, zoster incidence declined 9% per year. This trend occurred despite decreasing CD4 cell counts and was unexplained by zidovudine or acyclovir use.
UR - https://www.scopus.com/pages/publications/0032750926
UR - https://www.scopus.com/pages/publications/0032750926#tab=citedBy
U2 - 10.1086/315146
DO - 10.1086/315146
M3 - Article
C2 - 10558932
AN - SCOPUS:0032750926
SN - 0022-1899
VL - 180
SP - 1784
EP - 1789
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -